WCl6/DMF as a new reagent system for the phosphine-free Pd(0)-catalyzed aminocarbonylation of aryl halides?
RSC Advances Pub Date: 2014-09-04 DOI: 10.1039/C4RA04673K
Abstract
WCl6 in dimethyl formamide (DMF) is introduced as a new reagent system for aminocarbonylation of aryl halides in the presence of PdCl2 as pre-catalyst without any phosphorous ligand. Aryl iodides, bromides as well as chlorides were efficiently converted to their corresponding N,N-dimethyl amides in good to high yields. In this protocol, WCl6/DMF is responsible for the generation of both Pd(0) catalyst as well as the formation of a Vilsmeier imminium type intermediate.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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