Synthesis of (±)-kainic acid by dearomatising cyclisation of a lithiated N-benzyl p-anisamide
Chemical Communications Pub Date: 2000-02-10 DOI: 10.1039/A909325G
Abstract
N-Benzyl p-anisamide 6, on lithiation with ButLi in the presence of HMPA, undergoes a stereoselective anionic cyclisation with loss of aromaticity to give a bicyclic enone which may be converted in nine steps to (±)-kainic acid.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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