Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling?
Organic & Biomolecular Chemistry Pub Date: 2011-03-10 DOI: 10.1039/C0OB00925C
Abstract
A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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