Study on the accelerated Gutknecht self-cyclocondensation of amino-sugars under atmospheric pressure chemical ionization conditions?
RSC Advances Pub Date: 2015-12-01 DOI: 10.1039/C5RA22331H
Abstract
An unexpected gas phase Gutknecht self-condensation of D-glucosamine hydrochloride to 2,5-deoxyfructosazine (2,5-DOF) in atmospheric pressure chemical ionization mass spectrometry (APCI-MS) was described. Mechanistic studies indicated that the thermospray conditions in APCI largely accelerate the irreversible Gutknecht self-cyclocondensation reaction of amino-sugars. Our observations provide a promising clue for a new borate-free synthetic method of 2,5-DOF by mimicking the APCI conditions.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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