Stereoselective sulfenylation of oxindole-derived propargyl alcohols to access sulfenylated-3-alkenyloxindoles?
Organic & Biomolecular Chemistry Pub Date: 2021-11-12 DOI: 10.1039/D1OB01921J
Abstract
A Ca-catalyzed, tetrasubstituted alkenyl-sulfenylation was achieved using readily available aryl/alkyl thiols and easily prepared oxindole-derived propargyl alcohols under solvent-free conditions. The reaction proceeded with hydrogen bonding assisted regioselective α-thiolation and subsequent calcium catalyzed stereoselective alkenylation to yield E-alkenyl thioethers with high diastereoselectivity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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