Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
Natural Product Reports Pub Date: 2012-01-23 DOI: 10.1039/C2NP00088A
Abstract
Covering: 1972 to 2011
Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure–activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
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Journal Name：Natural Product Reports
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CAS no.: 89640-58-4
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