Synthesis of 3,3′-carbonyl-bis(chromones) and their activity as mammalian alkaline phosphatase inhibitors?
Organic & Biomolecular Chemistry Pub Date: 2015-10-15 DOI: 10.1039/C5OB01350J
Abstract
Hitherto unknown 3,3′-carbonyl-bis(chromones) 8, dimeric chromones bridged by a carbonyl group, were prepared by reaction of chromone-3-carboxylic acid chloride with 3-(dimethylamino)-1- (2-hydroxyphenyl)-2-propen-1-ones 9. The method is generally applicable for the synthesis of novel symmetrical or non-symmetrical products which were found to inhibit mammalian alkaline phosphatases.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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