Towards taxane analogues synthesis by dienyne ring closing metathesis??

Organic Chemistry Frontiers Pub Date: 2016-08-18 DOI: 10.1039/C6QO00321D

Abstract

Herein we report the facile construction of taxadiene analogues by ring closing metathesis of dienynes built on a cyclohexenone with a natural configuration at C1 and its further transformation to incorporate most of the key functional groups of taxol.

Graphical abstract: Towards taxane analogues synthesis by dienyne ring closing metathesis
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