A synthetic route towards 3,4-disubstituted pyrrolidin-2-ones via a Michael addition and reductive ring closing strategy?
New Journal of Chemistry Pub Date: 2017-03-30 DOI: 10.1039/C6NJ04051A
Abstract
Pyrrolidin-2-one derivatives were synthesized via DABCO mediated Michael addition of isoxazol-5(4H)-ones with nitroalkenes, followed by one pot reduction of the nitro group and ring cleavage with cyclization. 2-Pyrrolidinone scaffolds with a wide range of substituents were synthesized with good yield and diastereoselectivity by using this protocol.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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