Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates

Organic & Biomolecular Chemistry Pub Date: 2007-01-18 DOI: 10.1039/B615230A

Abstract

A series of nucleotide analogues wherein the diphosphate moiety has been replaced by a dicarboxylate were synthesized and tested for inhibitory activity against nucleoside diphosphate (NDP) kinase as well as several pathogenic bacterial strains.

Graphical abstract: Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates
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