The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine?
Organic & Biomolecular Chemistry Pub Date: 2015-11-27 DOI: 10.1039/C5OB02047F
Abstract
(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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