Ziprasidone malate, a new trimorphic salt with improved aqueous solubility?

CrystEngComm Pub Date: 2009-01-21 DOI: 10.1039/B813401D

Abstract

A new salt of ziprasidone with high aqueous solubility has been discovered as a result of a salt screening and it has been found to exist in three anhydrous polymorphic forms. One of these forms shows the highest aqueous solubility ever reported for ziprasidone salts in combination with a high kinetic stability, becoming a good candidate for further pharmaceutical development.

Graphical abstract: Ziprasidone malate, a new trimorphic salt with improved aqueous solubility
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