Transition-metal-free decarboxylative ipso amination of aryl carboxylic acids?
Organic Chemistry Frontiers Pub Date: 2021-04-27 DOI: 10.1039/D1QO00442E
Abstract
A convenient DMAP-catalysed decarboxylative amination of aryl and alkyl carboxylic acids is developed under transition-metal-free conditions. This reaction allows the sustainable synthesis of a wide range of aryl and alkyl amines in useful to good yields, avoiding the use of any activating reagent, transition-metal catalyst and external oxidant. The late-stage modification of bioactive acids and concise synthesis of carbamate and ureas demonstrated the synthetic potential of this methodology.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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