Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds

Organic Chemistry Frontiers Pub Date: 2014-06-19 DOI: 10.1039/C4QO00154K

Abstract

Chemical transformations via catalytic C–H bond activation have been established as one of the most powerful tools in organic synthetic chemistry. Transition-metal-catalyzed direct functionalization of β-C(sp3)–H bonds of carbonyl compounds has been developed in recent years. This highlight will focus on recent advances in this active area and their mechanisms are also discussed.

Graphical abstract: Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds
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