Sterically demanding aryl–alkyl Suzuki–Miyaura coupling?
Organic Chemistry Frontiers Pub Date: 2014-03-17 DOI: 10.1039/C4QO00024B
Abstract
Efficient sterically demanding aryl–alkyl Suzuki–Miyaura coupling between di-ortho-substituted aryl halides and secondary alkylboronic acids has been achieved with a Pd-AntPhos catalyst that has shown high reactivity and a broad substrate scope with unprecedented steric hindrance. The methodology has facilitated the synthesis of molecular gears such as by cross-coupling.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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