A unique fluorescence biosensor for selective detection of tryptophan and histidine?

Analyst Pub Date: 2014-07-16 DOI: 10.1039/C4AN00829D

Abstract

A novel photoinduced electron transfer (PET) based substituted calix[4]arene fluoroionophore has been used for the selective recognition of tryptophan (L-Trp) and histidine (L-His) by emission spectroscopy. The detection limit of the synthesized receptor was found to be 0.00826 nM for L-Trp and 0.00158 nM for L-His. Moreover, this probe has been applied for the recognition of L-Trp and L-His from blood serum.

Graphical abstract: A unique fluorescence biosensor for selective detection of tryptophan and histidine
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