The catalyst free synthesis of α-fluorinated aroylacyl imides?

New Journal of Chemistry Pub Date: 2016-07-12 DOI: 10.1039/C6NJ01122E

Abstract

The first approach to α-fluorination of aroylacyl imides without a catalyst was accomplished, relying on electrophilic activation through the reaction between a fluoride salt, dimethylsulfoxide and an imide. The synthesis of α-fluorinated aroylacyl imides in good yields was achieved using inexpensive reagents such as NaF and DMSO.

Graphical abstract: The catalyst free synthesis of α-fluorinated aroylacyl imides
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