Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane?

Organic & Biomolecular Chemistry Pub Date: 2011-08-25 DOI: 10.1039/C1OB05965C

Abstract

A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.

Graphical abstract: Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane
Recommended Literature