Sonogashira cross-coupling reactions of 3,5-dibromo-2,6-dichloropyridine?
Organic & Biomolecular Chemistry Pub Date: 2017-01-17 DOI: 10.1039/C6OB02264B
Abstract
A new method for the chemoselective synthesis of alkynylpyridines from 3,5-dibromo-2,6-dichloropyridine has been developed. Optimized conditions give access to a variety of mono-, di-, tri- and tetraalkynylated pyridines in good yields. Interestingly, the employment of 3,5-dibromo-2,6-dichloropyridine as a starting material led to the opposite regioisomers of dialkynylated pyridines as compared to the application of 2,3,5,6-tetrachloropyridine.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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