Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid?
Organic & Biomolecular Chemistry Pub Date: 2018-04-30 DOI: 10.1039/C8OB00810H
Abstract
Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid. A broad range of indoles were transformed into the corresponding 3-formylindoles in moderate to good yields and excellent functional group tolerance. Notably, no N-formylation product was detected under our conditions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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