Rh-Catalyzed aminative dearomatization of 2-naphthols?
Organic & Biomolecular Chemistry Pub Date: 2018-10-31 DOI: 10.1039/C8OB02592D
Abstract
A direct aminative dearomatization of 2-naphthols was achieved. In the presence of 1 mol% Rh2(esp)2 and 3 equivalents of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as readily available aminating reagents, the reactions of 2-naphthols afforded unprotected α-amino-β-naphthalenones in good yields under mild reaction conditions. The conditions were compatible with gram-scale reaction, and the product could undergo diverse transformations.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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