Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles?
Chemical Communications Pub Date: 2014-04-03 DOI: 10.1039/C4CC01738B
Abstract
Tandem reaction of 2-alkynylbenzonitriles with a Reformatsky reagent turned out to be a novel and efficient approach toward 1-aminonaphthalene-2-carboxylates. Interestingly, with 2-(3-hydroxyprop-1-ynyl)benzonitriles as the substrates, a more sophisticated cascade process occurred to give 9-aminonaphtho[2,3-c]furan-1(3H)-ones in good yields. By using this tandem reaction as a key step, a concise and versatile synthetic strategy for the total synthesis of arylnaphthalene lactone lignans has been developed.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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