A straightforward synthesis of 2-aminobenzothiazoles from Herz compounds??

Organic & Biomolecular Chemistry Pub Date: 2011-04-06 DOI: 10.1039/C1OB05398A

Abstract

2-Aminobenzothiazoles are readily synthesised from anilines, sulfur monochloride and isocyanides. The key step consists of an iodine-catalysed insertion of isocyanides into the S–S bond of hydrolysed Herz salts, with concomitant extrusion of sulfur monoxide.

Graphical abstract: A straightforward synthesis of 2-aminobenzothiazoles from Herz compounds
Recommended Literature