Trifluoromethyl ketones: properties, preparation, and application
Chemical Communications Pub Date: 2013-10-14 DOI: 10.1039/C3CC46266H
Abstract
Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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