Trienamines derived from 5-substituted furfurals: remote ε-functionalization of 2,4-dienals?
Organic & Biomolecular Chemistry Pub Date: 2014-09-23 DOI: 10.1039/C4OB01759E
Abstract
The selective ε-functionalization of 5-substituted furfurals via trienamine intermediates is reported herein. This methodology was successfully applied to several 5-substituted furfurals with different amines via formation of a trienamine through the furan ring. The rationalized reaction mechanism involves the addition of the trienamine intermediate to its corresponding iminium-ion producing new furan-containing scaffolds.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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