Transition-metal- and oxidant-free directed anodic C–H sulfonylation of N,N-disubstituted anilines with sulfinates?

Chemical Communications Pub Date: 2019-06-28 DOI: 10.1039/C9CC03789F

Abstract

A new, practical directed anodic C–H sulfonylation of N,N-disubstituted anilines with sodium sulfinates for producing o- or p-amino arylsulfones and diarylsulfones is described. Employing the anodic strategy, the reaction proceeds efficiently under mild (room temperature) and transition-metal- and chemical oxidant-free conditions, and enables the formation of C–S bonds via directed activation of ortho- or para-C–H bond to the amino group with broad substrate scope and excellent site selectivity.

Graphical abstract: Transition-metal- and oxidant-free directed anodic C–H sulfonylation of N,N-disubstituted anilines with sulfinates
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