Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides?
RSC Advances Pub Date: 2021-04-14 DOI: 10.1039/D1RA01522B
Abstract
Herein, direct alkylation of the C–H bond at the α-position of furans catalyzed by palladium catalyst is reported. This protocol targets α-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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