Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality?
New Journal of Chemistry Pub Date: 2016-09-19 DOI: 10.1039/C6NJ01956K
Abstract
1?:?1 and 2?:?2 oligomeric piperazinophanes with an intraannular ester functionality have been synthesized via Mannich reaction of various aromatic esters with piperazine by a one-pot reaction under benign conditions through the multicomponent reaction methodology. The newly synthesized piperazinophanes were characterized using spectral and analytical methods. The ester based 1?:?1 oligomeric piperazinophanes exhibit good target binding ability in molecular docking studies and also show better antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyogenes bacteria than the 2?:?2 oligomeric piperazinophanes.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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