Synthon polymorphs of sulfacetamide–acetamide cocrystal based on N–H?OS and N–H?OC hydrogen bonding?

CrystEngComm Pub Date: 2013-07-15 DOI: 10.1039/C3CE41179F

Abstract

A rare case of polymorphism in SO2–NH–C[double bond, length as m-dash]O containing molecules is reported in the 1?:?1 cocrystal of sulfacetamide (SACT) and acetamide (ACT). The R44(16) ring motif in polymorph 1 is assembled via N–H?O[double bond, length as m-dash]S and N–H?O[double bond, length as m-dash]C H-bonds whereas a similar hydrogen-bonded ring motif made of N–H?O[double bond, length as m-dash]C H-bonds only is present in form 2.

Graphical abstract: Synthon polymorphs of sulfacetamide–acetamide cocrystal based on N–H?O [[double bond, length as m-dash]] S and N–H?O [[double bond, length as m-dash]] C hydrogen bonding
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