Synthetic approaches to monofluoroalkenes

Chemical Society Reviews Pub Date: 2011-03-11 DOI: 10.1039/C0CS00201A

Abstract

Monofluoroalkenes are an important fluorinated class of compounds with applications in medicinal chemistry, material sciences and organic chemistry. An overview of methods allowing synthetic access to these fluorinated building blocks is provided. In particular, this critical review, which covers publications up to October 2010, will be divided according to the substitution pattern of the monofluoroalkenes, i.e. di-, tri- or tetra-substituted. Within each group, the various synthetic approaches will be divided according to the reaction type (282 references).

Graphical abstract: Synthetic approaches to monofluoroalkenes
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