Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes

Chemical Communications Pub Date: 2002-07-01 DOI: 10.1039/B204994P

Abstract

The synthesis of taurospongin A has been achieved using, as a key step, a π-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.

Graphical abstract: Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
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