2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

Natural Product Reports Pub Date: 2018-07-24 DOI: 10.1039/C8NP00051D

Abstract

Covering: up to April 2018

2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.

Graphical abstract: 2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis
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