Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands?
RSC Medicinal Chemistry Pub Date: 2021-03-26 DOI: 10.1039/D0MD00428F
Abstract
The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.
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Journal Name：RSC Medicinal Chemistry
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CAS no.: 89640-58-4
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