6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes?

Chemical Communications Pub Date: 2008-11-12 DOI: 10.1039/B816876H

Abstract

6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AG[X with combining low line] GCA AC-3′/3′-AGG TC[N with combining low line] CGT TG-5′, [X with combining low line] = AP site (Spacer C3), [N with combining low line] = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.

Graphical abstract: 6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes
Recommended Literature