Regioselective 1,2-addition of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives?
Organic & Biomolecular Chemistry Pub Date: 2017-04-19 DOI: 10.1039/C7OB00882A
Abstract
A strategy for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides is presented. This reaction was conducted under very mild conditions and gave up to 99% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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