A three-component reaction of arynes, sodium sulfinates, and aldehydes toward 2-sulfonyl benzyl alcohol derivatives?
Organic & Biomolecular Chemistry Pub Date: 2021-07-27 DOI: 10.1039/D1OB01229K
Abstract
A novel three-component reaction of arynes, sodium sulfinates, and aldehydes under mild reaction conditions is described. This transformation provides a direct synthetic approach to 2-sulfonyl benzyl alcohol derivatives, which could be rapidly converted to diverse arylsulfur compounds via the transformation of the corresponding hydroxyl groups. Various aryne precursors, sodium arenesulfinates, and aromatic aldehydes can be effectively converted to the desired products in 40–84% yields (29 examples).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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