Solvent-controlled highly regio-selective thieno[2,3-b]indole formation under metal-free conditions?
Green Chemistry Pub Date: 2017-10-24 DOI: 10.1039/C7GC02818K
Abstract
An efficient three-component thieno[2,3-b]indole formation method was developed under metal-free conditions. The cascade cyclization was enabled by acid-promoted annulation of indoles, ketones and sulfur powder, which enabled modular synthesis of 2-substituted and 3-substituted thieno[2,3-b]indoles with excellent regioselectivity and broad functional group tolerance. DMF solvent played an important role in the regioselectivity control.
![Graphical abstract: Solvent-controlled highly regio-selective thieno[2,3-b]indole formation under metal-free conditions](http://scimg.chem960.com/usr/1/C7GC02818K.jpg)
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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