Recent progress in the radical α-C(sp3)–H functionalization of ketones

Organic & Biomolecular Chemistry Pub Date: 2021-08-17 DOI: 10.1039/D1OB01408K

Abstract

The direct use structurally simple ketones as α-ketone radical sources for α-C(sp3)–H functionalization is a sustainable and powerful approach for constructing complex and multifunctional chemical scaffolds with diverse applications. The reactions of α-ketone radicals with alkenes, alkynes, enynes, imides, and imidazo[1,2-a]pyridines have broadened the structural diversity and complexity of ketones. Through chosen illustrative examples, we outline the recent progress in the development of methods that enable the radical α-C(sp3)–H functionalization of ketones, with an emphasis on radical initiation systems and possible mechanisms of the transformations. The application of these strategies is illustrated by the synthesis of several biologically active molecules and drug molecules. Further subdivision is based on substrate type and reaction type.

Graphical abstract: Recent progress in the radical α-C(sp3)–H functionalization of ketones
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