Recent applications of the hetero Diels–Alder reaction in the total synthesis of natural products

RSC Advances Pub Date: 2015-11-16 DOI: 10.1039/C5RA17488K

Abstract

The synthetic utility and potential power of the Diels–Alder (D–A) reaction in organic chemistry is evident. These significances have been extended to the synthesis of a plethora and wide variety of heterocyclic compounds via [4 + 2] cycloaddition reactions, the so called hetero Diels–Alder (HDA) reaction. In this work we try to focus on the scope and preparative synthetic applications of the HDA reaction as a key step in the total synthesis of natural products.

Graphical abstract: Recent applications of the hetero Diels–Alder reaction in the total synthesis of natural products
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