Acemetacin polymorphs: a rare case of carboxylic acid catemer and dimer synthons??

CrystEngComm Pub Date: 2012-10-22 DOI: 10.1039/C2CE26534F

Abstract

Acemetacin is the first example of an API polymorph with a carboxylic acid catemer and dimer O–H?O synthons. The auxiliary stabilization to the catemer motif from stronger C–H?O and C–Cl?O interactions compared to those in the dimer structure is discussed for a polymorph pair. The crystal structure of the stable dimer polymorph was solved by structure determination from powder X-ray diffraction data (SDPD).

Graphical abstract: Acemetacin polymorphs: a rare case of carboxylic acid catemer and dimer synthons
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