Stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalyzed by Pregosin's hydrido complexes of type Ru(H)(p-cymene)(bis-phosphine)(SbF6)?

Catalysis Science & Technology Pub Date: 2012-08-23 DOI: 10.1039/C2CY20335A

Abstract

Pregosin's complex Ru(H)(p-cymene)((R)-DTBM-Segphos)(SbF6) has been shown to be an efficient catalyst for stereoselective asymmetric hydrogenation of 2-benzamido-methyl-3-oxobutanoate to syn-(2S,3R)-methyl-2-(benzamido-methyl)-3-hydroxybutanoate in high diastereoselectivity and enantioselectivity in ethanol.

Graphical abstract: Stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalyzed by Pregosin's hydrido complexes of type Ru(H)(p-cymene)(bis-phosphine)(SbF6)
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