Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions?
Organic & Biomolecular Chemistry Pub Date: 2014-05-23 DOI: 10.1039/C4OB00400K
Abstract
N-Substituted 2-iodobenzamides and enaminones undergo cascade transformations to achieve quinazolinones via a copper-catalyzed Ullmann-type coupling, a Michael addition and a retro-Mannich reaction. A unique stereochemical feature of this domino process was that Z-enaminones reacted without external ligands, whereas E-enaminones required the assistance of ligands.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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