Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones?
Organic & Biomolecular Chemistry Pub Date: 2017-11-29 DOI: 10.1039/C7OB02576A
Abstract
An efficient approach for the preparation of pyrazoles via a Pd(II)/Cu(I)-catalyzed Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones has been established. In this study, we firstly report the strategic use of a Sonogashira reaction to construct pyrazole rings in a one step operation. With a broad range of functional group tolerance, bioactive 3-CF3 pyrazoles can also be synthesized easily through this domino coupling/cyclization sequence.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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