Absolute asymmetric synthesis of a sanguinarine derivative through crystal–solution interactions?

CrystEngComm Pub Date: 2016-09-29 DOI: 10.1039/C6CE01765G

Abstract

A new construction reaction for the absolute asymmetric synthesis of a sanguinarine derivative was realized by crystal–solution interactions. A stochastic outcome with high enantiomeric excess (ee%) values (up to 100%) was observed under cooling crystallization, while preferential chiral amplification was observed with Viedma ripening.

Graphical abstract: Absolute asymmetric synthesis of a sanguinarine derivative through crystal–solution interactions
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