A silver(i)-catalyzed tandem reaction of 2-alkynylbenzaldoximes with ketenes?

Organic & Biomolecular Chemistry Pub Date: 2013-02-26 DOI: 10.1039/C3OB27427F

Abstract

A novel and unexpected reaction of 2-alkynylbenzaldoximes with ketenes in the presence of silver triflate (10 mol%) under mild conditions is discovered. This reaction proceeds through 6-endo-cyclization, [3 + 2] cycloaddition, and rearrangement, leading to isoquinoline derivatives in moderate to good yields.

Graphical abstract: A silver(i)-catalyzed tandem reaction of 2-alkynylbenzaldoximes with ketenes
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