Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation?
Chemical Communications Pub Date: 2018-03-27 DOI: 10.1039/C8CC01568F
Abstract
An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C–F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by C–F bond activation.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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