Pharmacokinetic/pharmacodynamic modelling of effective components of Fangji Huangqi Tang for its treatment of nephrotic syndrome

New Journal of Chemistry Pub Date: 2018-11-17 DOI: 10.1039/C8NJ03040E

Abstract

This study was designed to evaluate the potential effective components of Fangji Huangqi Tang for the treatment of nephrotic syndrome based on a pharmacokinetic/pharmacodynamic model. To quantify the relationships between the pharmacokinetics and pharmacodynamics of fangchinoline and tetrandrine, the pharmacokinetic/pharmacodynamic model was set up by combining pharmacokinetic parameters and the effective indexes in rats. Compared with a model group, the effective indexes including serum urea nitrogen, cysteine protease inhibitors C, total cholesterol and triglycerides in the FHT group became significantly lower with a dosing time extension. The pharmacokinetic/pharmacodynamic modeling results showed that there were good linear relationships between the areas under the concentration-time curves and these effective indexes. Finally, fangchinoline and tetrandrine were proved to be the main effective chemical materials of FHT to cure nephrotic syndrome in rats.

Graphical abstract: Pharmacokinetic/pharmacodynamic modelling of effective components of Fangji Huangqi Tang for its treatment of nephrotic syndrome
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