5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex?

Chemical Communications Pub Date: 2004-11-30 DOI: 10.1039/B414474K

Abstract

NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.

Graphical abstract: 5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex
Recommended Literature