Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology?

Chemical Communications Pub Date: 2012-03-20 DOI: 10.1039/C2CC30844D

Abstract

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives.

Graphical abstract: Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology
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