Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives?

Chemical Communications Pub Date: 2021-07-21 DOI: 10.1039/D1CC03477D

Abstract

An unprecedented enantioselective conjugate addition reaction of sodium bisulfite to various nitrostyrenes occurred upon the influence of a bifunctional amino-thiourea organocatalyst; a strategy that opens a straightforward route to unprotected chiral taurine derivatives thanks to the reduction of the obtained β-nitroethanesulfonic acids into the corresponding amino derivatives.

Graphical abstract: Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives
Recommended Literature